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Post cycle therapy (PCT) If you are new to steroid cycle use, following the PCT cycle is equally importantas in the early cycle.In the early cycle, it is important that you take a normal dose of estrogen (see below). However, if you have had previous therapy on estrogen and your symptoms or liver function improves, then you may consider increasing the dose to the equivalent of 2.5mg of estradiol per 10ml of blood.After the PCT, the cycle should be resumed with a dose of estrogen similar to what you would have taken had the first cycle not been a PCT.If after two cycles of estrogen-free cycle treatment you wish to start taking estrogen on a daily basis, you may wish to increase your estradiol dose by 0.5 to 2mg/day on a daily basis.Estrogen levels should go down within three weeks. If they stay too high, then they are likely to be low or non-responsive to anti-hypertensive medication and you may have a cycle with a low dose of estrogen.If there is not some improvement, then return to the PCT cycle.If there is some improvement then you should take a 0.005 to 0.5mg estradiol/kg/day dose.If you do not improve or there is no further improvement, then you have a higher risk of developing a cycle with a high dose of estrogen and then having a high dose of estrogen.Estrogen should be discontinued after one month, unless there is a reason to continue. If the hormone does not decrease or levels remain too high even after 1 month, then you may be at increased risk of developing post cycle toxicity. In this case the dose may need further investigation into the potential for an interaction or a complication with the progestogen/estrogen complex.The risk of bleeding from a high dose of estrogen may outweigh the risk of side effects if the following are observed:Symptoms that worsen during the cycle, such as headache or nauseaDiabetesChronic liver disease (e.g. cirrhosis)High blood pressureObesityInsulin resistanceOsteoporosisProblems with blood vessels/bone massTobacco or alcohol use (See WARNINGS below)The risk of bleeding from a low dose of estrogen may outweigh the risk of side effects if the following are observed:Symptoms that improve during the cycle, such as headache or nauseaDiSimilar articles: